CDKN2A hypermethylation had an unfavourable impact on OS of patients with colorectal cancer (HR 1.65, 95% CI 1.29 2.11).
Specifically, in that study diseases of the retina with a very similar impact on visual health, like macular degeneration, showed an unfavourable impact on quality of life.
First, the total number of candidates would have remained unchanged across the compared genomic scenarios, thus limiting the unfavourable impact on selection intensity of genotyping only a proportion of the candidates.
Higher total fat intake including fat rich foods such as meat products and dairy is a point of concern in light of the high prevalence of obesity, among Iranians living in Sweden and can have an unfavourable impact on cardiovascular health of this immigrant group.
The changes in the pressure tube geometries have an unfavourable impact on the operation of the reactor where the aged reactor overall power output must be reduced in order to maintain the same safety margin as the new reactor.
We have previously reported that MRI-detected CN invasion had an unfavourable impact on the prognosis of NPC (Liu et al, 2009).
Overexpression or amplification of HER2 occurs in 15 30% of breast carcinomas and is considered to confer a more aggressive biology and an unfavourable impact on the course of the disease (Slamon et al, 1987).
Gene amplification of HER2 (HER2/ neu, c-erbB2) receptor tyrosine kinase (RTK) is found in 10 to 25% of invasive breast carcinomas [ 1, 2] and is associated with an unfavourable impact on the course of disease and reduced responsiveness to tamoxifen therapy, for example [ 3, 4].
The relatively large scale of these projects necessitates correction for multiple tests and will therefore have an unfavourable impact on sample size and power of such studies.
