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The large majority belonged to the low intermediate group (n = 44, 59%) and the unfavourable group (n = 25, 34%).
The outcome of patients with tumours demonstrating ⩽two adverse features (favourable group) was compared to those patients with ⩾three adverse features (unfavourable group).
Two groups of samples were thus defined: an 'Unfavourable group' defined by a positive score and a 'Favourable group' defined by a negative score.
Whereas the unfavourable group consisted of TS genotypes associated with elevated TS levels: 2R/3RG, 3RC/3RG and 3RG/3RG (Mandola et al, 2003; Marcuello et al, 2004).
For endothelial cell proliferation and vessel maturation, 16 patients from the unfavourable group and 18 patients from the favourable group were randomly selected.
In this subset, 'Favourable' cases had a 2-year and a 5-year PFS of 55% and 38%, respectively, vs 0% in the 'Unfavourable' group (P=2.56E-05, log-rank test).
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By controlling the physical and social environment, an attempt is made to destroy loyalties to any unfavourable groups or individuals, to demonstrate to the individual that his attitudes and patterns of thinking are incorrect and must be changed, and to develop loyalty and unquestioning obedience to the ruling party.
On the contrary, unfavourable groups included three repeat genotypes with a G allele (2GC/3G, 3G/3C, 3G/3G).
Comparisons between the favourable and unfavourable groups were performed using the chi-square or Fisher's exact tests for frequencies.
Previous work has suggested that the patients with a diagnosis of CUP should be categorised into favourable and unfavourable groups prior to considering therapy.
The number of cycles of chemotherapy (ABVD regimen (adriamycin, bleomycin, vinblastine, dacarbazine) as standard) depends on prognostic subgroups, three cycles for favourable groups and four cycles for unfavourable groups.
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