To calculate the sample size of the pharmacogenomic study, the expected frequency of unfavourable genotypes and its effect on RR and DFS was assessed.
Winter months, for example, exhibit a higher frequency of unfavourable cardiovascular events, such as acute myocardial infarction and sudden cardiac death [ 2- 4], aortic rupture or dissection [ 5, 6], stroke [ 7], and venous thromboembolism [ 8, 9].
Previous studies in Western countries show that TN breast cancer has aggressive clinical and pathologic features, including onset at a young age, advanced stage at diagnosis, high histologic and nuclear grade, high mitotic index, higher frequency of unfavourable histologies, and more distant recurrence [ 8, 10, 12, 15].
These older patients have a much reduced capacity to tolerate high dose chemotherapy and their leukaemia's are associated with higher frequencies of unfavourable prognostic factors [5].
Case series document unusually aggressive disease, including a higher frequency of the unfavourable histological subtypes (mixed cellularity and lymphocyte depleted), advanced stages and poor therapeutic response compared with the behaviour of HD outside of the HIV setting.
For unfavourable indoor air in East Germany, the frequency of colds was increased, but of eczema and sensitisation decreased.
This study offers unique opportunities to assess the frequency of occurrence of unfavourable outcomes following donation and allows risk factors associated with them to be determined.
Furthermore, the frequencies of small living place, unfavourable indoor air and damp housing condition decreased over time, the latter also with a peak in the mid-nineties.
Thus, rather than employing a Tanimoto coefficient or a Euclidean distance, our PADIF similarity score is basically constructed by counting matching favourable interactions weighted by frequency and decreasing the score upon unfavourable interactions again weighted by frequency.
This life-history strategy has probably evolved both in response to the challenges of living at sea (collecting widely scattered prey items), the frequency of breeding failures due to unfavourable marine conditions, and the relative lack of predation compared to that of land-living birds.
