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By analysing a broad range of parameter values, we were able to evaluate the sensitivity of selected variables by using a range of favourable and unfavourable estimates.
This assumes that only the estimated effect size influences whether a study is included in the meta-analysis or not, so that studies with the most extreme unfavourable estimates of effect are excluded [ 11, 14].
For example, under severe level of PB, where the meta-analysis size ought to be 30, 50 studies are generated so that 20 studies (i.e. 30% of the original 50 studies) giving the most extreme unfavourable estimates are omitted from the meta-analysis.
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The first estimate of PET scan costs was taken from 2005 Medicare Reimbursement rates, and the second cost estimate (unfavourable screening estimate) was taken from a 2004 published cost-effectiveness study by Kelly et al (2004) (Table 1).
And what are the characteristics of RA patients with an unfavourable prognosis, estimated by radiological joint damage, for which more aggressive therapy is indicated?
Previous analyses on cost-effectiveness assumed slightly lower between-dose efficacies for RotaTeq® compared to Rotarix®, resulting in a more unfavourable cost-effectiveness estimate for RotaTeq® [ 8, 9].
It has been estimated that unfavourable climatic conditions and inappropriate soil can account for over 70% of the yield loss of major crops (Boyer 1982).
Applying the conservative assumption that an equal proportion of patients with missing data had an unfavourable pain outcome, we estimate that at least 7%–23% of patients experienced long-term pain after hip replacement.
The maximum possible error for the angles values at end movement (i.e., the angle values reported in Table 3) was, under unfavourable and pessimistic conditions, estimated to be 7 degrees for AAF R and 6.5 degrees for EA R in the RM and 4.8 degrees for EA M in the HtMM.
The use of different splits than the conventional favourable vs. unfavourable outcome resulted in rather different estimates of the treatment effect (Table 3).
Previously, several models to estimate the probability of unfavourable outcome after aSAH have been developed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com