Keller and colleagues (and GSK in subsequent correspondence) ignored unfavourable harms data on the grounds that the difference between paroxetine and placebo was not statistically significant, at odds with the SKB protocol that called for primary comparisons to be made using descriptive statistics.
In the most unfavourable case, in which data were interpreted unfavourably in five instances to create a very highly unlikely scenario, the mobile screening unit had an incremental cost effectiveness ratio of about £26 000 (table 4).
On the whole, the genetic correlation estimated between BW and its uniformity was unfavourable when untransformed BW data were used but favourable when log-transformed BW data were used.
CYFRA 21-1 may serve as a valuable tool for monitoring treatment response and assessing prognosis in advanced PC. Pancreatic cancer (PC) is a neoplastic disease known for its unfavourable prognosis and outcome data: the 5-year relative survival rate among patients diagnosed with PC in the United States from 2001 to 2007 was as low as 6% over all stages (Siegel et al, 2012).
EPHT data showed an unfavourable effect of HT on CVD, but not statistically significant.
This includes the conscious desire to avoid publishing data that are unfavourable to a particular intervention.
Conversely, analysis of IGF-1 data showed an unfavourable outcome in patients presenting serum levels < 90 mUI/mL at days 15 and 30.
In MPC, the initial molecular data explaining their unfavourable clinical course were recently identified, with HER2/neu gene amplification, amongst others, as a frequent molecular alteration in this variant [ 20].
Applying the conservative assumption that an equal proportion of patients with missing data had an unfavourable pain outcome, we estimate that at least 7%–23% of patients experienced long-term pain after hip replacement.
65, 66 While a large armamentarium of treatment options for IBS-C is available, the majority of these options lack proven efficacy from clinical trial data and/or have unfavourable side-effect profiles.
