Exact(4)
The potential limitations notwithstanding, our study showed that combinations containing a taxane agent demonstrated a prolongation of the median survival time and higher 1-year survival rate in the first-line treatment of unfavourable CUP compared with those without taxanes.
This systematic review and meta-analysis utilising all available clinical trials fills an important gap of certainty in the current evidence by demonstrating a beneficial effect in the use of taxane for unfavourable CUP patients.
A recent multiple treatment comparison meta-analysis based on a small number of RCTs on chemotherapy regimens in unfavourable CUP patients reported great uncertainty about the survival benefit of any particular regimen (Golfinopoulos et al, 2009).
As the efficacy of chemotherapy for patients with unfavourable CUP has mostly been assessed in the setting of small phase II trials without controls, data from limited numbers of RCTs are insufficient evidence for the superiority of any particular regimen in terms of survival prolongation.
Similar(56)
The consequence will be an unfavourable 2015 World Cup draw when it is made on 3 December, with two other sides from the top eight in the rankings in their pool.
Studies on chemotherapy for the unfavourable subset of CUP were included.
These new therapeutic approaches may represent an exciting and promising way of improving the unfavourable prognosis in CUP patients.
However, for the unfavourable subset of CUP patients, there has been no clear understanding of the survival benefits by any chemotherapeutic treatment so far, although platinum- or taxane-based regimens have been commonly and empirically used in current clinical practice.
Although chemotherapeutic regimens containing a taxane or platinum agent have been widely recommended for unfavourable carcinoma of unknown primary (CUP), no evidence exists for the superiority of any administered regimens.
The European Society for Medical Oncology guideline lists recommended chemotherapeutic approaches containing platinums and taxanes as commonly used low-toxicity chemotherapy regimens, but stated that no evidence exists for superior efficacy of any of the administered regimens for unfavourable carcinoma of unknown primary (CUP) patients (Fizazi et al, 2011).
The 1960s saw the rivalry reach the European stage when they met twice in a controversial knock-out round of the European Cup, with Madrid receiving unfavourable treatment from the referee.
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