His case was funded by the United Motorcycle Council of Queensland, who chose him for his lack of assets in case of an unfavourable costs order.
Swaziland, Botswana and South Africa have relatively unfavourable cost-effectiveness in relation to their disease burden.
Previous analyses on cost-effectiveness assumed slightly lower between-dose efficacies for RotaTeq® compared to Rotarix®, resulting in a more unfavourable cost-effectiveness estimate for RotaTeq® [ 8, 9].
However one must bear in mind that currently MR-colonography is hampered by its limited availability, unfavourable cost-effectiveness and longer examination time.
22 In fact, unfavourable cost-to-benefit analysis has led to the rejection of applications for approval of orphan drugs by the UK National Institute for Health and Care Excellence.
Furthermore, at current price differences between CRT-P and CRT-D, small incremental benefits of CRT-D versus CRT-P result in relatively unfavourable cost-effectiveness ratios for CRT-D.
Compared with no screening, periodic or annual screening of 40-years old adults resulted in rather unfavourable cost-utility ratios (US$68,000/€60,00000 to US $260,600/€220,00000 per QALY).
The main cause for tiotropium's unfavourable cost-effectiveness ratio is a combination of a relative high price for tiotropium, a low number of hospitalisations without tiotropium treatment (on average 0.14/year) and a non-significant treatment effect (on average 0.94) with respect to avoiding exacerbation-related hospitalisations.
The odds for people with asplenia were low in the study, with no obvious increased probability of developing disease, resulting in unfavourable incremental cost effectiveness ratios.
The thermodynamic parameters of enthalpy change (Δ H=−29.1 kcal/mol) and entropy change (TΔS=−18.9 kcal/mol) indicate that the binding is driven by enthalpy with a very unfavourable entropic cost.
