Sentence examples for unfavourable contribution from inspiring English sources

This helps cholesterol to avoid the exposure of hydrophobic membrane regions to water which would give rise to a very unfavourable contribution to the free energy.

Examination of Table 2 and Figure 1 indicates that proline at P4 results in an overall unfavourable contribution to binding, while arginine makes a contribution which is overall nearly neutral.

The analysis of contribution by position again showed good binding for the motif in both native and constructed cases, and many unfavourable contributions in the context of non-native interactions (Figure S3).

Thus both enthalpy and entropy contribute about equally to binding, despite the unfavourable entropy contribution of bringing ligand and receptor together to form one species.

However, trimethylated H4K20 has a large desolvation term compared to its coulombic term and this result in a highly unfavourable electrostatic contribution to the total binding free energy difference.

Analysis of the ITC data revealed a slightly unfavourable entropic contribution (Δ S=−14.4 cal/mol per K), possibly indicating that the Dat structure was slightly stabilized upon binding to AcCoA and that very few solvent molecules were freed from the binding pocket (solvent entropy).

It also leads to an increase in the cytosolic redox state which makes the conversion of lactate to pyruvate unfavourable and thus limits the contribution of lactate to gluconeogenic flux [ 45].

Isothermal titration calorimetry experiments have revealed a thermodynamic signature for this interaction (very favourable enthalpic contributions opposed by an unfavourable binding entropy) inconsistent with the highly hydrophobic nature of the p41 ligand and the Abl-SH3 binding site.

This special relationship attracted unfavourable attention since it was associated with "political contributions" (see below) and support for anti-democratic politics, as evidenced by papers taken from the body of a Gulf executive killed in the crash of a TWA aircraft at Cairo in 1950.

Results confirm that interactions in blends of polyesters and polycarbonate can be exothermic when certain compositional requirements are satisfied; however, the model predicts exclusively endothermic mixing for all binary polyester blends and that in these situations, miscibility occurs only when the entropic contribution to the free energy of mixing overwhelms the unfavourable interaction.

Its contribution to HCO3- secretion is unlikely because of the unfavourable gradient or it is possibly indirect through regulation of HCO3- transporters [ 65].