Exact(8)
Applied to these samples, the seven-gene OPM defined a 'Favourable' class (n=187; 51%) and an 'Unfavourable' class (n=179; 49%) that strongly correlated with survival.
Moving from Radiation Therapy Oncology Group (RTOG)'s RPA to their new 4-tiered GPA score, the size of the most unfavourable class can be reduced from 39to34%4%.
However, the most unfavourable class contains only 2 patients and the most favourable class only 7. For the score developed by Rades et al., the difference between the 2 unfavourable classes is not statistically significant either.
Once the best model was defined (OPM), a prediction score, defined by a Cox resulting linear function, was then calculated for each sample, thus defining two classes: the 'Unfavourable' class with a positive score and the 'Favourable' class with a negative score.
Importantly, when applied to a large independent validation set (N=366), which represents so far the largest one reported in the literature, our model maintained its strong and independent prognostic value in multivariate analysis with 5-year OS of 57% in the 'Favourable' class and 27% in the 'Unfavourable' class.
From this 94-gene list, we established a seven-gene OPM able to classify, independently from classical prognostic features, our samples in two classes with different clinical outcome: a 'Favourable' with 5-year OS of 56%, and an 'Unfavourable' class with 5-year OS of 10%.
Similar(52)
Five-year OS was 57 and 27% for the predicted 'Favourable' and 'Unfavourable' classes, respectively.
In the BSBM system, the difference between the 2 unfavourable classes is not statistically significant.
The prediction score (OPM) defined two classes: 'Unfavourable' (positive score) and 'Favourable' (negative score).
This market rational, guided by public-private investments and city branding, could however result in (a) a collection of sanitized city spaces specifically designed for the upper classes with unfavourable activities pushed outward, and (b) a homogenization of different destinations, without sufficient attention for the space-specific characteristics.
Furthermore, in our series KPS <70, age >65 years, presence of other extra-cranial metastases and RPA class III represent unfavourable factors for response.
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