Sentence examples for unfavorable expression from inspiring English sources

Patients were divided into 4 groups, based on the number of markers showing clinically favorable or unfavorable expression.

Multivariate trend analyses showed significantly increased hazard ratios (HR) for each additional marker showing unfavorable expression, as compared to the "all favorable" reference group.

Resulting hazard ratios (HR) represent the HR for each unit of increase (increase in group number, and hence an increase in the number of markers showing unfavorable expression).

Therefore, using multivariate trend analyses, we calculated hazard ratios for each additional marker showing unfavorable expression, as compared to the "all favorable" reference group.

Both univariate and multivariate trend analyses showed that the more markers showed unfavorable expression, the shorter the patient survival (DSS) and recurrence-free survival times (both LRRFS and DRFS).

With each additional marker showing more unfavorable expression, the HR increased significantly about 3-fold for DSS, LRRFS and DRFS, indicating that combining all three methylation marks resulted in better separation of the patient groups as compared to individual markers.

Furthermore, low FOXP1 transcript levels significantly correlated with unfavorable gene expression-based classification according to a prognostic multigene classifier that we have defined previously [ 26].

The challenges faced by these therapies include the following: lack of predictive and response biomarkers, unfavorable safety profiles, expression of targets not restricted to the cancer cells, flawed preclinical model systems, drug resistance, and PDA's complex nature.

However, unfavorable smooth interfaces of expression domains occur if expression is only regulated by a morphogen in our case Fgf8[ 30].

High rates of protein expression or unfavorable conditions for protein folding cause inclusion bodies formation.

Likewise, despite the documented unfavorable value of p16 expression in NPC [ 7, 35], such a role did not emerge in our study.