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This is probably the most challenging and unexplored issue in this context.
An interesting, but relatively unexplored issue concerns the relative importance of thought experiments in different disciplines.
An interesting, largely unexplored issue is whether ontogenetic shifts occur in allocation to reproduction in mahogany (Norghauer, pers. observ).
An important but largely unexplored issue is the extent that experience as an author affects his/her behavior as a reviewer and vice versa.
An unexplored issue for nitrogen fixation in A. ferrooxidans is the oxygen sensitivity of the nitrogenase enzyme.
Still, timing of occurrence of ocular surface changes when starting IOP-lowering treatments is an unexplored issue.
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This provides some unexplored issues of engineering design.
But with the President's surprise attack on Mr. Jaworski's authority to sue the President, new and relatively unexplored issues have been raised.
Unexplored issues (target CO2 purity, cost curves, hybrid processes, role of water, minor components) are finally exposed as major research targets.
One of the unexplored issues in the tragic shooting of Amadou Diallo is the role that semiautomatic pistols played in the discharge of 41 bullets by four police officers in a few seconds (front page, Feb. 3).
At its best, such political art criticism can be enlightening and bring to the fore previously unexplored issues; at its worst, it can be didactic, dogmatic, intolerant, and forced.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com