Based on emerging data, I make the case that fresh efforts employing next-generation DNA sequencing to discover and define genetic mitochondrial defects in unexplained cardiomyopathy (Man et al, 2013) are likely to uncover novel rare and pathophysiologically significant primary mitochondrial disorders of the heart.
Through an unexplained mutation a man is born with blood that will never let him grow old.
Doom metal and unexplained cosmic energies, man.
A hypothesis worth testing would be that there is still some unexplained difference between men and women in the development of pain, while differences between men and women who already have pain can to a larger extent be explained by exposure to known risk factors.
Putting money into supposed treatments that don't work could mean financing unhappiness and divorce, leaving women's feelings invisible or unexplained, and placing men on insecure ground.
"In fact," says the National Women's Law Center, "authoritative studies show that even when all relevant career and family attributes are taken into account, there is still a significant, unexplained gap in men's and women's earnings".
While other possible factors, such as healthcare utilisation and health behaviours, were not considered, it is possible that these may also be important as downstream factors, and could also account for the larger unexplained portion in men's health gap.
Since 1967, the ureaplasmas have been shown as an etiology of male infertility [ 23], and especially when Friberg and Gnarpe [ 24] first demonstrated a higher frequency of ureaplasmas in the semen of men with unexplained infertility (76%) compared with fertile men (19%).
Initial evidence suggested that with increasing age, there will be decreasing testosterone as one study found that 4% of otherwise healthy men with unexplained azoospermia carried mutations in NR5A1 and that these men may also be at risk of endocrine dysfunction with failing testosterone with increasing age.
In 1942 she helped establish a defense committee for hundreds of Mexican Americans who were wrongfully arrested and detained in Los Angeles after the unexplained death of a man in an incident that came to be known as the Sleepy Lagoon murder.
