Unexpectedly, a minimal helicase module containing the RecA sandwich and the zinc finger domain but lacking the Winged-Helix domain has been recently described, which can unwind a fork substrate in vitro[ 24].
Since ROS-enhancing small molecules unexpectedly had minimal effects on the growth and viability of cancer cell lines, we prioritized 80 nontoxic screening hits that strongly enhanced ROS levels in U2OS for deeper characterization in cellular viability and oxidative stress assays.
This multigenesis of cancer-initiating cells (CICs) may also explain why there was even some "unexpectedly high genetic divergence" in "minimal residual cancer" [ 31].
This multigenesis of cancer-initiating cells (CICs) may also explain why there was even some "unexpectedly high genetic divergence" in "minimal residual cancer [ 31]." We should also point out that the parallel mutagenesis for multigenesis of anatomically separate cancers is different from "the parallel evolution model" for metastasis [ 32].
For example, the Mycoplasma agalactiae genome, long assumed to have undergone genome reduction in order to become one of the simplest free-living organisms with a minimal genome, was unexpectedly found to have a large fraction of predicted genes – 18% - likely acquired by HGT from species in distinct phylogenetic groups [ 31].
Unexpectedly, the Tsc1-null livers showed minimal signs of steatosis even under high-fat diet condition.
Unexpectedly, concerns about security and privacy were minimal, although it is unknown whether this was because the implications of the theft or misuse of the personal identification data were not fully understood.
The evidence destruction and the safety concerns were minimal, as the officers entered Callahan's home unexpectedly.
Unexpectedly, despite up-regulation of CREB phosphorylation, MCMV-infected ES cells exhibited a minimal responded to high-concentration FSK stimulation (Figure 4A and 4B).
Unexpectedly the widely invasive FTC clustered closer to the FTA than to the minimal invasive FTC.
Unexpectedly, L2AKO mice also displayed higher ROS levels at early ages (Fig. 7E), despite the minimal pathological changes observed in these livers (Fig. S7A).
