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We observed efficient gene targeting but found that targeted clones carried an unexpectedly high frequency of insertion and deletion (indel) mutations at both alleles of the targeted gene.
Furthermore, there is an unexpectedly high frequency of perfect colocalization (Figure 2, Table 1): Of the 68 ncRNA molecules analyzed, 18 (26.5%) map entirely within prominent DSB peaks.
We found an unexpectedly high frequency of CXCR4-using viruses in the CD14high CD16− monocytes, even in some patients who had only CCR5-using viruses in their CD4+ T-cells.
Our initial studies showed an unexpectedly high frequency of inflammation associated with the invasive tumour component.
Experimental evolution under controlled in vivo conditions in gnotobiotic piglets showed an unexpectedly high frequency of HGT between the co-colonizing S. aureus isolates.
In order to understand the unexpectedly high frequency of the c.1138G>A mutation and its highly clustered distribution in the testis, we consider several computational models.
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Pathological reports have shown unexpectedly high-frequency of small or microscopic GISTs in resection specimens for gastroesophageal malignancies.
Despite a low frequency of only 2.6% in Japan during 2007 08 season, an unexpectedly high frequency (32.4%) of ORVs was observed in Tottori prefecture.
The theory is supported by the experimental finding that clonal mosaicism occurs at unexpectedly high frequency in human tissues as a function of time, not only in adults due to aging (Jacobs et al., 2012; Laurie et al., 2012), but also in human embryos (Vanneste et al., 2009).
Since the treatment of postmenopausal breast cancer patients with aminoglutethimide caused hypothyroidism with an unexpectedly high frequency previous treatment was suspected to contribute to hypofunction of the thyroid.
Measurement of MGE transfer between S. aureus revealed unexpectedly high frequencies during host colonization in vivo.
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