Although the first clinical trial with the AN-1792 vaccine was halted because of unexpected cerebral inflammation detected in a subset of participants, presumably due to infiltration of autoreactive T cells rather than anti-Aβ antibody, caused the significant adverse effects in the vaccinated patients [9], [10], [12].
However, many patients with RA fail to respond to this or other biologics, and some patients may suffer unexpected aggravation of arthritic inflammation or other autoimmune effects.
Finally, the treatment with low E3 combined with lactobacilli had a profound and unexpected effect on vaginal inflammation.
Steroid therapy was increased incrementally as the severity of the inflammation was totally unexpected.
The persistence of increased protein concentrations of MAO-B was unexpected, even though some haematological and inflammation characteristics remain modified for several years after quitting smoking [19], [35], [36].
These unexpected properties might contribute to limit inflammation and viral spreading in HIV-1 infected patients under PIs treatment, and open novel therapeutical perspectives for this class drugs as immunomodulators in autoimmunity and cancer.
Recent seminal works have also shed new light onto B-cell regulatory functions in the context of immune-mediated inflammation and revealed an unexpected role of B cells in bone homeostasis.
Scientists may yet discover that inflammation contributes to disease in unexpected ways.
This is not unexpected in view of the link between inflammation and joint damage progression [ 4, 41, 42].
In contrast, our study did not find any unexpected MRI changes suggestive of ischemia, infarction, inflammation, or volume loss in patients with HA, beyond that seen in the nonhypoglycemic T2DM population.
