We found that a major and unexpected determinant of the abundance of footprints from each conformation was the identity of the amino acid encoded by the A-site codon.
This was unexpected, because one determinant of radial diffusivity is the degree of axonal myelination (Beaulieu, 2002) and, as this increases, one might expect reduced radial diffusivity, faster nerve conduction times (Jack et al., 1983) and more efficient executive function.
Furthermore, unexpected relationships between the determinants of serum free oestradiol levels and mammographic densities suggest that manipulation of SHBG levels or function could also be beneficial.
The finding that the same peptide is effective in both HLA DRB1*0401 and HLA DRB1*0101 is somewhat surprising but not totally unexpected because the immunodominant determinant, CII256 276, is common to both DR1 and DR4 transgenic mice.
Liao et al. studied the correlations between evolutionary rates of mouse paralogs and several genic parameters and remarked that "because there are potentially many rate determinants...it is not unexpected that the observed correlation coefficients are not very high"[33].
Such differences in key developmental transcription factors and hormones are perhaps not unexpected as these may be major determinants of Agave morphological adaptations to xeric environments.
Somewhat it is unexpected to note that the molecular determinant is a genetically-recessive point-mutation of W60G in fadR locus (Figs. 2 and 5).
A perhaps not unexpected result is that the most important determinant of relative risk for malaria was human population density, assuming as we do here for Africa that (i) ecological and demographic factors rather than control measures are the determinants of risk and (ii) parasite densities are sufficiently high for disease spread.
A somewhat unexpected finding is that many of these predicted specificity determinants lie within the DHHC domain, since this domain is highly conserved between all PATs studied and between different species.
This unexpected finding will complicate the task of identifying virulence determinants in the Brucella genus.
