As the box office started to stumble, the elements that had made his movies different — the Pennsylvania settings, the themes about faith, the unexpected endings — became a basis for criticism.
Thus, SFR may explain the mechanistic basis for unexpected alterations in cellular signaling, for example, due to gain or loss-of-function mutations found in human diseases [11], [12].
The molecular basis for the unexpected response upon treatment with the CD28 superagonist TGN1412 is as yet unclear.
To explore the basis for this unexpected result, we pursued detailed biochemical studies of recombinant M284K-hGALE.
The basis for this unexpected finding is not clear, although it might reflect a different organisation of the cytoskeleton in different cell types (Martin-Villar et al, 2006).
To determine the biological basis for the unexpected cell cycle arrest in TPA-treated HRBECs, lysates were analyzed to gauge the induction of DNA damage pathway proteins.
To examine the basis for the unexpected reduced structural effects of dianionic versus monoanionic phosphothreonine at residue 5 of the α-helix, peptides were synthesized with threonine or phosphothreonine at residue 10 of the α-helix.
Further analyses of p53 downstream effectors (e.g., the cyclin/cyclin-dependent kinase inhibitor p21Waf1) may provide a basis for the unexpected absence of a G1 checkpoint in irradiated SVZ NSPs.
To understand the molecular basis for the unexpected drug binding affinities exhibited by the QacR(E57Q) and QacR(E58Q) mutants, we conducted X-ray crystallographic experiments with these QacR mutants in complexes with Be, Dq, and MG.
The mechanistic basis for the unexpected selectivity of the SR2F in antagonizing the pro-metastatic effects of TGF-β while sparing effects on tumor suppression and normal homeostasis is currently not clear, but it does not seem to be a dosage effect.
