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The occurrence of deeply conserved and species-specific miRNAs in metazoan, argues in favor of a permanent, rapid and uneven evolutionary process of miRNA genes emergence [ 2].
The presence of deeply conserved and species-specific miRNAs, in various plant species, points towards a continuous, rapid and uneven evolutionary process of miRNA genes [ 4, 7].
The reasons for this may be earlier expansions of these families, uneven evolutionary rates among the daughter genes, gene conversion between family members or simply translocation of distant family members to the chromosomes in this study.
One of these implications is that the uneven evolutionary rates of coral mitochondrial sequences do not reflect evolutionary divergence time and are therefore suboptimal to resolve phylogenetic relationships within the order Scleractinia.
The evolutionary relationships of the NPY-receptor family receptors in vertebrates have been difficult to resolve due to uneven evolutionary rates and because some subtypes are missing in some classes of vertebrates.
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SSU rDNA analyses also depicted a very deep phylogeny with many large gaps (long unbroken branches), suggesting large numbers of missing species and/or highly uneven SSU rDNA evolutionary rates [ 11].
Remarkably, we show here that PapC is characterised by an uneven distribution of the evolutionary important residues, clustered in the P-linkers, the PD, and the barrel wall capped by the α-helix, in close proximity to the β-hairpin.
Beyond that conclusion, however, the results were quite uncertain due to the low information content of the alignment, between-branch differences in the evolutionary rates, and uneven sampling of different groups.
This suggested that actin genes included in the two types of clades experienced similar evolutionary time, but undergone uneven selections.
For the analysis of the fly genome, we overcome the uneven full-genome sampling of the evolutionary tree from human to fly by taking advantage of the recent sequencing and annotation efforts of 12 species from the Drosophila genus [ 32].
For the latter genome, we overcome the uneven full-genome sampling of the evolutionary tree from human to fly by taking advantage of the recent sequencing and annotations efforts for 12 species from the Drosophila genus [ 32].
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