Exact(1)
The only complete assurance against such potential biases is to undertake recordings of clinical encounters without informed consent - clearly an unethical design.
Similar(57)
Five respondents had experienced unethical pressure concerning design/method and five had experienced unethical pressure concerning results, while one had experienced harassment.
Lastly, residual confounding by disease severity could explain differences between categories, but control of this would demand randomized controlled trials; in this setting, an unethical study design.
The primary reasons cited for the Cameroon trial closure were: inadequate access to care for seroconverters (69%); participants not sufficiently informed of risks (69%); inadequate number of staff (46%); participants being exploited (46%) and an unethical study design (38%).
Other major allegations included an inadequate number of support staff (6/13) [ 12, 36, 39- 41, 54], participants being exploited and treated like 'guinea pigs'(6/13) [ 12, 36, 39- 41, 54], an unethical study design (5/13) [ 12, 36, 40- 44] 44] and finally, the belief that trial is only being conducted in Cameroon to promote Gilead's commercial prospect (5/13) [ 12, 40- 44] 44].
In an e-mail, Mark Nieker, president of the Pearson Foundation, wrote, "We once again categorically refute any suggestion that the events are in any way unethical or designed to enable Pearson to win contracts".
Firstly, some authors have argued that underpowered trials are unethical and trials designed with delta inflation are essentially underpowered [ 38].
However, this design is often considered impractical by infection control personnel and may be unethical in outbreak settings.
Before the meeting, many researchers felt that this design would be unethical, knowing that health care workers are at considerable risk and Ebola is so often fatal.
However studies with this design are considered unethical given the benefit of chemotherapy.
This is a misnomer, because any clinical trial carried out without rigour and without a proper design would be unethical.
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