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As Margarita Holmes says in her excellent blog, In Spark: The Revolutionary New Science of Exercise and the Brain by John J. Ratey and Eric Hagerman (2008), the proof that exercise is truly our best defense against depression is unequivocally presented.
In step 1, the exclusion of irrelevant studies was decided by considering only the title and abstract; when the abstract of a particular article was not available, the article was selected for evaluation in step 2, except when the title unequivocally presented information for exclusion (e.g. case report, studies of risk factors in a specified population).
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Solutions to these dilemmas do not unequivocally present themselves, but we hope to stir a colloquy among our colleagues.
We can't take the locus to be "everything in the world", for many such things are not effects (e.g. atoms, space) and so The Manual of Reason's desired reason will again not be unequivocally present in the locus.
The influence of the prenatal environment on mental health later in life is unequivocally present.
Gls II, GT and calreticulin were not only present in the rough ER, as expected, but also in the smooth ER and unequivocally present in pre-Golgi intermediates.
Another patient was excluded because postoperative findings associated with a partial meniscectomy of the anterior horn of the lateral meniscus were unequivocally present on follow-up MRI, although data on the procedure were missing on the questionnaires.
Antibodies against β-cell antigens were reported to be unequivocally present in just one patient; in this patient results were negative at the time diabetes was diagnosed and became positive only during follow-up.
Mutations were identified by visual inspection of sequences provided by the ABI basecaller, and called when unequivocally present on the sense and/or antisense strand, and when the area under the curve of peaks changed by more than 5%, compared to the area under the curve of the normal signal.
The data presented herein unequivocally show that ventral abdominal contractions are an integral component of the mosquito circulatory system.
Our previously published work, together with the new data presented here, unequivocally demonstrate that Mer is required for TAM ligand-dependent phagocytosis of ACs by GC-treated BMDM.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com