However, COI-5P resolved three distinct genetic groups that are divergent from one another by 6-10% and thus unequivocally distinct species.
Accordingly, we maintain that our qualitative conclusions relating to "faster" and "slower" tumors are at least as valid, if not moreso, using the Ki67 cutoffs specified in the manuscript, given that this splits the comparison into two unequivocally distinct (i.e., numerically discontinuous) groups.
Our use of pronuclear assembly in egg extract and fractionation of staged embryos into soluble and chromatin fractions permitted us to unequivocally assign distinct abundances to both undeposited and chromatin bound histones using high resolution mass spectrometry.
Performing FISH with BAC and cDNA clones on chromosomes of one representative of the New World monkeys, the black-handed spider monkey, we could unequivocally map distinct PKD1-signals distal in 1q26 (Fig. 4a, AG E, which could be defined as the orthologous region to human chromosome 16 [ 32].
Despite these potential limitations, our study revealed consistent trends across distinct populations unequivocally linking network complexity and local population performance.
Combined, these studies unequivocally show that genetically distinct variants of tumour cells exist within individual tumours in multiple tumour types.
Although the existence of alternative forms of fructose bisphosphate aldolase, phosphoglycerate mutase and superoxide dismutase has been known for many years, recent studies have led to a dramatic increase of the number of such cases [ 13, 14], including many where alternative enzyme forms have been unequivocally shown to adopt distinct structural folds (Table 1 and Additional file 2, Table S2).
Overall, no distinct traits can unequivocally link the evolutionary history of CRP-I peptides with those of other protein families characterized by the same cysteine array.
The report acknowledged that Thailand's penal code does not define torture as a distinct criminal offense or unequivocally prohibit courts from using evidence obtained through torture.
In additional experiments, in which we conducted affinity purification of MEL18 in cells expressing FLAG-tagged RING1 and HA-tagged RING2, or vice versa, we demonstrated unequivocally that RING1 and RING2 are present in distinct complexes (Supplementary Fig. S2).
Due to the lack of distinct characteristics, it is generally not feasible to unequivocally identify personal care products as source of microplastics detected in the environment.
