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There were six partial responses (three rhabdomyosarcoma, three neuroblastoma) after two courses, but because of variation in the dose and schedule of etoposide these cannot be unequivocally contributed to MDR reversal.
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Although of unclear etiology, the failing β-cell function unequivocally contributes to the glycemic instability (21).
In summary, irradiating aging cells that already display an unbalanced oxidant antioxidant status would unequivocally contribute to overload the antioxidant systems (Fig. 1).
MAOs-related oxidative stress unequivocally contributes to acute myocardial ischemia/reperfusion injury [ 91] and to the mitochondrial dysfunction and pathologic hypertrophy elicited by pressure overload in a murine model of HF [ 92, 93].
Irradiating aged cells that already contain an increased amount of ROS would unequivocally contribute to overload the antioxidant systems responsible for eliminating the excess of oxygen metabolites (Fig. 1).
Second, although several lines of evidence strongly suggest a contributory role for galectin-3 in the pathophysiology of heart failure, we lack proof-of-principle experiments (eg, in galectin-3 deficient mice or in pharmacologic studies) to show that galectin-3 is unequivocally contributing to the onset and progression of cardiac remodeling.
Humans are now unequivocally implicated in contributing to global climate change [ 1, 2].
All of which contributed to her being unequivocally unhappy about being where she was.
Salvadorean authorities have unequivocally blamed the carnage on the gangs, but drug traffickers have also contributed to the mayhem.
These findings unequivocally demonstrate that the callosal input contributes to enhancing the detection of specific aspects of the visual input by activating a specific transhemispheric neuronal assembly.
We therefore do not unequivocally reject the idea that higher mutation rates contribute to the evolvability advantage of robust lineages under heat shock.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com