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This hypothesis is reinforced by the rapid kinetics of fibrilization and the presence of high molecular weight oligomers upon substitution of the charged K14 with an uncharged side-chain (Ala), which demonstrated the unequivocal involvement of the positive charge of the K14 side-chain.
Among the many genes that have been studied, only two that encode extracellular matrix (ECM) proteases have been explored [ 2- 6], despite the unequivocal involvement of this family of proteins in RA.
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Chemical modification studies along with site-directed mutagenesis have provided unequivocal proof of the involvement of S475 in the active site of TPP1.
Taken together, these data demonstrated that TbMyo1 plays an essential role in endocytic traffic in bloodstream forms and provided the first unequivocal demonstration of the involvement of a motor protein in this traffic in these parasites.
Results presented here provide unequivocal evidence for the involvement of GLD-1 in the meiotic development of spermatocytes in both hermaphrodites and males.
As explained in the introduction, whereas the literature on visual word recognition provides unequivocal support for the involvement of occipitotemporal/fusiform regions during unconscious perception, the literature on face recognition has not reached the same conclusion.
"This is a rare case for unequivocal evidence for clear human involvement," says lead author Vladimir Pitulko, also of the Russian Academy of Sciences.
Because of the intrinsic nature of biological systems and processes, the unequivocal identification of a gene's involvement in a specific process is nontrivial.
Michael Barnett I am disgusted by your failure to give an unequivocal "No" to Bush on any UK involvement in the missile defence strategy.
Despite considerable efforts hardly any of the candidate gene analyses (exceptions: 5HT2A receptor; BDNF; see Table 2) has yielded unequivocal and clearly confirmed evidence for the involvement of specific alleles in the etiology of eating disorders.
"Arafat and the Palestinian leadership have to give a clear and unequivocal instruction to stop terror, to stop the involvement of its own people in murderous activities".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com