Besides its unequivocal role in modulating immune responses, STAT1 also possesses non-immune functions, such as the regulation of bone formation and destruction under homeostatic and pathological conditions.
In contrast, (hypo mania-associated chypo mania-associatedinition, has to be achangenind by an unequivocal change in functioning.
A change in mood in the direction of elevated mood, for example, is primarily a subjective experience, not necessarily associated with an unequivocal change in functioning - and thereby not necessarily easily accessible to others.
Therefore, finding out whether, at some point in the past, there has been a change in mood, associated with an unequivocal change in functioning, that is uncharacteristic of the individual when not symptomatic may significantly depend on the information provided by others, such as close friends, relatives or partners.
Of these, the splicing (c.87+1G>A and c.194+2T>C) and frameshift (c.27delC and c.98_99insA) mutations, the gross deletions (c.1-320_c.55+961del1336bp andeletionof of the entire gene), and the p.M1T initiation codon mutation represent unequivocal loss-of-function mutations.
However, an unequivocal understanding of gene function generally requires that a transgene functions throughout the plant's life and is transmitted through the sexual cycle, since this alone allows its effect to be decoupled from the plant's response to the generally stressful gene transfer event.
The change in renal function is unequivocal.
The weakly transported nature of l-pipecolic acid via PAT2 demonstrates that it will have limited utility as a tool to provide unequivocal evidence for PAT2 function in native tissues.
Unequivocal answer about the functions of IP3R1 and IP3R2 for cardiac development awaits further study of cell-specific conditional knockout mice.
SP I H135A was an active nuclease, with mismatch recognition properties similar to those of the wild type SP I, indicating that H135 is dispensable for the mismatch nuclease activity of SP I. Expression of a protein in a heterogeneous host followed by purification is an important step in the study of protein function, allowing the unequivocal assignment of a function to a polypeptide.
