Exact(5)
Although lithium's low therapeutic index had the potential to elicit untoward effects during a 4-month survival study, we sought to duplicate exactly the dosing regimen used by Fornai et al. [1] because it showed unequivocal efficacy, and this efficacy was linked to efficacy in ALS patients.
A completed Phase III randomised clinical trial can yield unequivocal efficacy data.
Fulvestrant is the only ER antagonist that has demonstrated unequivocal efficacy in patients with tamoxifen-resistant advanced breast cancer.
However, despite their unequivocal efficacy, there is still considerable room for additional cardiovascular risk reduction in patients.
Drotrecogin alfa (activated) (DrotAA), also known as human recombinant APC, was shown to improve outcome after sepsis, but unsuccessful clinical trials of DrotAA treatment of less severe patients and children have questioned the unequivocal efficacy of this drug [ 50].
Similar(55)
There was no unequivocal evidence of efficacy for any of the other antiepileptics.
Outbreaks of measles, a disease previously held in check, are making a comeback despite the unequivocal safety and efficacy of the MMR vaccine.
Later analyses will also include consideration of whether there is an unequivocal lack of efficacy.
Although MSC have potentially broad-reaching clinical applications in liver disease they have yet to demonstrate unequivocal evidence of efficacy.
Despite small randomized controlled trials of other pharmaco-prophylactic interventions (e.g. propranolol, hydrocortisone and gabapentin) not demonstrating unequivocal evidence of efficacy [ 20], with current investigations under way into the psychobiology of PTSD and the discovery of novel prophylactic targets, there is hope that efficacious preventive medications will be found [ 29].
However, despite tremendous efforts, no unequivocal proof of therapeutic efficacy could be shown in AD patients.
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