Unless evidence of the dependence of clinical benefit on biomarker classification is a priori unequivocal, personalized drug development needs to jointly investigate treatments and biomarkers in clinical trials.
For his part, Mr Marchionne insists that he has "a strong and unequivocal commitment to the development of Alfa Romeo" and that he is "determined to transform it into a full premium brand".Next year, Alfa will launch the Giulia, a replacement for the handsome but not quite good enough 159 saloon, that will lead the charge in America.
For his part, Mr Marchionne insists that he has "a strong and unequivocal commitment to the development of Alfa Romeo" and that he is "determined to transform it into a full premium brand".A new line-up Next year, Alfa will launch the Giulia, a replacement for the handsome but not quite good enough 159 saloon that will lead the charge in America.
Animals were euthanized upon development of unequivocal clinical signs.
Interactions between the IGF-I and ER-α/17β-estradiol in regulating mammary gland development are unequivocal.
HCAs with mutated β-catenin are more frequently interpreted as borderline lesions between HCA and HCC, and are more frequently associated with the development of unequivocal HCC than other subtypes of HCA [ 23, 28, 30].
Female cattle were kept until development of unequivocal signs of a neurological disease consistent with BSE or signs of any other untreatable or welfare compromising disease; surviving dosed cows were culled at 88 mpi together with age-matched control cows.
Today we got uncertainty in spades...this development is an unequivocal negative... most significantly for the cable operators and Verizon".
Statements like "long-term negative investment," "regulated price setting" and "this development is an unequivocal negative," show that a better plan is coveted by the marketplace.
She has also been far from unequivocal in her assurances that the development commissioner will be left political space to complete his objectives.
