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Although all of the EST sequences developed under the SGP [ 19, 20] are available to the community through NCBI, these ESTs represent an immense collection of unedited data to sift through and sequencing errors are common.
We found that we could calculate an analogous confidence interval metric if the data were adapted by reversing the region around the peak position and adding the RH frequencies of the reversed region to those of the original to create an approximately normal distribution while maintaining the variance of the unedited data.
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"The Internet is the epitome of an unedited information glut".
#Monthly air temperature and precipitation averages are from unedited local climatological data provided by NOAA, National Climatic Data Center for the Kalamazoo/Battle Creek International Airport (42°14'N Lat; 85°33'W Lon.; 892 ft elevation).
We requested the protocol, case report forms, and unedited databases containing individual patient data from investigators of all eligible trials.
In the 12 723 data set representing unedited sequences, the average number of seed matches to miR-769-3p/-450b-3p at ant 7 nt position was 0.79 (max = 4).
While the results analysed above are for the data in their original unedited state, we have also considered the effect of 'correcting' for likely data errors.
Based on our data, the target genes of unedited miRNAs are largely different from that of edited ones.
Reduced association with γ-2 in absence of the AMPAR NTD was also observed for GluA1 (data not shown) and for other GluA2 isoforms, namely unedited GluA2i-Q607 and for the alternatively spliced GluA2-flop variety GluA2o-R6077).
Given that the ratio of edited to unedited dADAR isoforms fine-tunes the global 'editosome' [ 21] as well as complex organismal behavior, these data point toward an intriguing role of thermal control in global RNA editing [ 9].
The responses are unedited.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com