Phosphorylated Ksr can also function as a transactivator; however, since Raf binding to Ksr induces limited kinase activity [27], in quiescent cells the constitutive association of Ksr with B-Raf may serve to prevent C-Raf binding to B-Raf, safeguarding against undue activation of the pathway [28].
In at least those experiments, possible poly-ubiquitination was apparently not effective or fast enough to prevent such undue intracellular activity.
To find modalities that would allow interfering with undue tumor-exosome activity, we explored tumor-exosome uptake and immune response modulation in a rat model.
Yet, in contrast, they also exhibited caution regarding movement that may cause pain, which could cause some confusion and lead to undue restriction of activity.
Keeping cookie-selling a girl-run activity, without undue parental assistance, has been a challenge.
Carney said that while the president is a "firm believer in the need for the press to be unfettered in its ability to conduct investigative reporting," he also "recognizes the need for the Justice Department to investigate alleged criminal activity without undue influence".
While gentle movement can help your nausea, odds are, most physical activity will cause undue stress to your stomach, which can worsen your nausea.
"You've got the constitutional principle that states have a right to conduct their activities autonomously without undue interference from the commonwealth".
Paradoxically, the key to mollifying them is to propose Pigovian taxes not just on vehicle weight but also on a swath of other activities that cause undue harm to others.
At a recent meeting of senior ministry officials where the proposal was discussed, some people expressed concern that high-profile matchmaking activities could impose undue pressure on unmarried workers, Taiwan media reported.
