Since autocrine PDGFR signalling and hypoxia are both tumour-associated events this may well be a paradigm for the identification of autophagic signalling pathways that could be utilised for targeting tumour-selective autophagy, and further studies of this, and other pathways, undoubtedly merit further investigation (Refs 114, 115; see also Fig. 2).
The debate surrounding each of these elements, although undoubtedly complex, merits resolution in advance of any further research.
Experts notoriously critique our generation, deeming us "Generation Stress," which undoubtedly has merit.
Calling for totem pole dialogue, as the DHCD has endorsed, on the "interconnectedness of the past, present and future of Anacostia" undoubtedly has merit.
As such, careful monitoring of decision-making responses (ie, ideally assessed daily in the initial stages during a hypoxic intervention) undoubtedly has merit.
Firstly, many of the drugs that have been trialed and discarded undoubtedly have merit if given for the right indication to the right patient, at the right time, in the right dose, and for the right duration.
Both approaches undoubtedly have merit, but while the authors suggest there is limited empirical support for the benefits of screening for distress as we have applied it, there appears to be even less support for the idea of 'supporting resilience and case finding'.
(The Roundabout staged an Off Broadway production in 1987, starring Philip Bosco.) "A Man for All Seasons" undoubtedly has its merits.
Undoubtedly, the great merit of these studies is that they have provided strong evidence in favour of the positive impact of PA on mental disorders, including major depression and anxiety.
While this approach undoubtedly has some merit, the main problem is that while these characteristics may confer elevated risk for distress, they do not fully account for all elevated distress; certainly there are many older individuals, for example, who suffer from elevated distress and could benefit from treatment.
