However, the notion that established risk factors have only modest importance in explaining socioeconomic differences in CVD, followed by a search for undiscovered risk factors, has been criticized [ 10, 11].
A number of approaches have been developed to address this issue, but the answers they provide depend on the assumptions inherent in different models of as-yet undiscovered genetic risk.
However, these risk factors explain only ∼60% of the risk, suggesting the existence of undiscovered or undefined risk factors.
McRae details the consequences of the feverish market for undiscovered places: needless risking of lives, dubious and bitterly contested claims about the lost falls, and an orgy of hype that culminated in National Geographic Adventure anointing Baker one of seven "explorers for the millennium".
The latter finding suggests there are undiscovered strong familial risk factors for early-onset breast cancer.
Our results probably underestimate the effects of the CRC SNPs on the multiple adenoma phenotype, because the publicly available population controls were not known to be adenoma-free; furthermore, there almost certainly exist undiscovered, common CRC risk variants.
The undiscovered share of genetic risk for common diseases, he said, probably lies not with rare variants, as suggested by Dr. Goldstein, but in unexpected biological mechanisms.
Facebook: #Undiscovered Twitter: @Undiscovered.
In popular mythology, moors are a bogland, a badland, an undiscovered bourn from which travellers risk failing to return.
This might have resulted in a heart fit's going undiscovered, but a double would have risked missing a 5-3 spade fit because that North hand was not strong enough to bid a second time opposite a minimum advance by South.
