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When patients present with undifferentiated problems, identifying their decision support needs ahead of a visit may be impossible.
Undifferentiated patient presentation Time-constrained decision-making Environmental illness and injury Prehospital care Transition point between community and hospital Focused history and exam Prioritized differential diagnoses.
DOI: http://dx.doi.org/10.7554/eLife.02260.006 Interestingly, the level of this decision bound was undifferentiated by the speed-accuracy regime.
The Hairy-enhancer of split (HES) family of bHLH factors act as transcriptional repressors and have roles in maintaining progenitor cells in an undifferentiated state and regulating cell fate decisions during embryogenesis.
To ensure the faithful development of multicellular organisms, cell fate decisions in populations of undifferentiated cells have to be tightly balanced.
Subsequent studies have demonstrated that this tool accurately estimates the risk of acute cardiac ischemia in an undifferentiated patient population, and substantially speeds decision making and triage by novice clinicians [22, 24 26].
This MACS rule was derived in accordance with established methodological guidance 14 and provides a bespoke tool to aid clinical decision making specifically in the undifferentiated ED population.
We indicated recently that synovial histopathology can be used for early diagnosis of undifferentiated arthritis (UA), with multiparameter models such as decision trees being superior to single parameters.
General practitioners and other primary care practitioners who see a high proportion of undifferentiated illness are particularly exposed to uncertainty in decision making.
To better understand stem cell function in tissues with an open niche environment, we investigated the mechanisms underlying the fate decision of Aundiff (whether to remain undifferentiated or to differentiate) during mouse spermatogenesis.
We therefore sought to derive and subsequently externally validate a customised clinical decision rule (CDR) to guide the management of undifferentiated patients presenting to the ED with possible cardiac chest pain.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com