W&W: watch and wait; Rx4: rituximab four weekly doses; Rx4 + RM: rituximab four weekly doses plus rituximab maintenance; CR: complete response; CRu: undetermined complete response; PR: partial response; ORR: overall response rate.
Nevertheless, it is worth underlining the fact that at least in one large scale study a negative evolution of the results over time, following a first period of clinical improvement, was hypothetically related to the event of an otherwise undetermined immune response [14].
A reduced response rate could produce an undetermined bias in the responses, which could influence the conclusions drawn from the results.
UBE3B is thought to play a role in the oxidative stress response in humans and Caenorhabditis elegans (Oeda et al. 2001), and UBE3C plays an undetermined role in inflammatory responses in the human airways, probably related to IκB ubiquitination (Pasaje et al. 2011).
These study conclusions are hedged with caveats (limitations of sample size due to online survey response rate, undetermined generalisability of the results), which might be addressed, at least partially, by expanding the study to other HEI institutions across the EU and, indeed, further afield.
In the analysis, each response to clinical problems was considered positive, negative, or undetermined (i.e. no response) when the imaging quality or the device technology failed to provide a definite diagnosis.
It is possible that the defense genes such as LRRs, a laccase, and a putative wall-bound xylosidase upregulated at this harvest date (8/16/12), (Pavir.J24695), were activated in response to an undetermined stress.
Though rare, AOSD-like PNS can be one of the potential diagnoses in lung cancer patients with fever of undetermined origin, especially those having no response to antibiotic treatment.
In patients with monoclonal gammopathy of undetermined significance (MGUS), anti-SOX2 T cell responses were found to be directed against a very small percentage of tumor cells which were of the clonogenic type [ 13].
Patients whose root level involvement remained undetermined were required to demonstrate a positive response to a fluoroscopically guided diagnostic selective nerve root block (SNRB).
