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On the other hand, undetectable virus at the end of treatment is coined as an end-of-treatment response (ETR).
In contrast, a recent study conducted in Kenya reported that only 12 388%) of 31 samples with undetectable virus by RNA PCR had undetectable RT activity [31].
The protective dose 50% (PD50) was determined by survival or undetectable virus titers in the lungs following challenge with H5N1 or H1N1 virus, respectively.
Since blips occurred across the different treatment groups, comparisons have been made based on the frequency of animals with typical viremia (not protected) versus those with undetectable virus or virus blips (protected).
Of these 60, 23/23 (100%) had undetectable virus based on Procleix testing on remnant serum, including 12 who had a short interval between initial confirmatory test and last repeat negative confirmatory test (< = 36 days).
Definitions of response to treatment were undetectable serum HCV-RNA levels 24 weeks after cessation of treatment as SVR, undetectable serum HCV-RNA levels at 4 week after starting treatment as RVR, at least two-log10 reduction of viral load at week 12 after starting treatment as EVR, and undetectable virus at the end of treatment as ETR.
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Some scientists are concerned that dangerous compounds or undetectable viruses will escape the multiple physical and chemical filters at the plant.
Patients with a chronic HBV infection lack such vigorous, polyclonal, and multispecific T cell responses, but instead exhibit a weak, narrowly focused, or undetectable virus-specific T cell response [ 2- 5].
Resting CD4+ T cells harboring provirus have been demonstrated in patients receiving HAART with undetectable plasma virus concentrations for extended time periods, and replication competent virus can be recovered from these cells after CD8+ T cell depletion in vitro.
Only a trend to increased CHOP mRNA, approaching statistical significance, was observed in HIV+ patients with undetectable plasma virus level (<50 copies/ml) compared to HC (Fig. 6B).
All of these patients had been on cART for a median of 84 months at the time of analysis (interquartile range, IQR [60 94]), and had had a sustained undetectable plasma virus load throughout follow-up.
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