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The control design was rather challenging because the system is highly nonlinear and because undesired interaction occurs between multiple illumination zones in a big office room.
Targeted drug delivery systems can directly deliver the payload to the desired site of action without undesired interaction with normal cells.
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As synthetic pathways built from exogenous enzymes become more complicated, the probability of encountering undesired interactions with host organisms increases, thereby lowering product titer.
The fundamentally important steps in creating highly selective phase systems include rigorous control of surface chemistry and adjustment of the final stationary phase properties by appropriate mobile phase selection, leading to specific solute-surface interactions and suppressing undesired interactions.
However, the heterogeneous biophysical chemistry of parts coupled with the inherent complexities of biological systems often lead to unpredictable behaviors that result from parasitic or otherwise undesired interactions among parts and with the host.
The X-ray structures of around 30 different DARPin complexes demonstrate their ability to facilitate crystallization of their target proteins by restricting flexibility and preventing undesired interactions of the target molecule.
In many ways medicinal chemistry provides a bridge between biology and chemistry, identifying novel compounds that modulate a biological response and thusproviding the tools to investigate biological processes, subsequently optimizing those compounds to avoid undesired interactions with other biological systems.
This causes clustering of positive charges around Lys112 and Lys115, and may result in structural destabilization by electrostatic repulsion and undesired interactions with negatively-charged molecules.
To prevent undesired interactions, the radiation dose on the first day of the third cycle was given before infusion of carboplatin and paclitaxel.
Drugs directed against these families should therefore be of broad specificity and target all Candida species, and are likely to have no undesired interactions with the human patient.
Undesired interactions due to high-surface charge, as observed in many other candidate materials, are addressed by the naturally weak electrostatic surface charge of the SBA-15 particles, which can be further modulated with surface functionalisation [53,43].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com