Sentence examples for undesirable pathway from inspiring English sources

This can be done by altering metabolic flux by blocking undesirable pathway(s) and/or enhancement of desirable pathway(s).

From a pharmacological perspective, it raises the intriguing possibility that specific compounds could be developed, which block the activation of an undesirable signalling pathway at a single chemokine receptor but leave intact the ability to activate a desirable signalling pathway.

Currently, CNTs and graphenes exhibit a broad range of energy levels, and bandgaps depend on the size, chirality, doping, and functionalization, all of which lead to undesirable charge pathways and limit further PCE enhancement.

Molecular chaperones are believed to prevent undesirable folding pathways such as premature folding, aggregation and misfolding and thereby facilitate formation of biologically active protein structures [ 9].

In this paper, we describe our efforts to overcome the above limitations, focusing on increasing phosphorescence quantum yield, improving efficiency of the antenna-core energy transfer, minimizing quenching of phosphorescence by undesirable intramolecular pathways, and optimizing the signal dynamic range.

Current challenges lie in the assembly and coordinated expression of the (non- native pathways anon- nativeination of compathwaysandways and undesirable regulathen.

Novel Notch1 targeting siRNA delivery system of siRNA-NPs showed effective RA treatment by suppressing Notch1 signaling pathway without undesirable severe toxicity.

However, the further improvement of GlcNAc titer is limited by the intrinsic inefficiency of GlcNAc synthetic pathway and undesirable cellular properties including sporulation and high maintenance metabolism.

Assuming a membrane orientation similar to the plasma membrane flippase (i.e. such that phospholipid is transferred to the cytosolic leaflet), one possible function for ATP8a1 would be to "recondition" surfactant internalized via the recycling pathway by removing undesirable phospholipid components such as lysoPC from the LB for transport back to the ER.

In conclusion, our data show a previously unrecognized genetic damage in myeloid cell upon pro-inflammatory activation, and suggest that the broad use of PTP1B inhibitors, although with potential benefits over the insulin signaling pathway, might exert undesirable effects in response to stressors of the immune system including the fine tuning of the pro-inflammatory and pro-resolution balance.

However, these data also suggest that the broad use of PTP1B inhibitors, although with potential benefits over the insulin signaling pathway, might exert undesirable effects on response to stressors of the immune system including the fine tuning of the pro-inflammatory and pro-resolution balance.