Once we identify a feature with a desirable property, such as affinity for a certain target molecule or lack thereof for an undesirable molecule, we must assure that it is homogeneously distributed throughout the device surface.
We also stress the importance of biomarkers for medical surveillance of populations at risk and propose the use of biosensors as sensitive resources to detect undesirable effects of new molecules and environmental pollutants.
In marine environments, the undesirable accumulation of organic molecules and microorganism on submerged surfaces is termed biofouling (Patel et al. 2003).
As stated before in perspectives by us and others, the fact that approved drugs may be repurposed for other diseases should not be viewed as a negative aspect of the small molecules, belying undesirable target promiscuity.
The more lipophilic molecule is undesirable not only for slowing passive brain entry but also for increasing high non-specific binding to brain fats and protein.
Significant differences were noted in LogP and Lipinski Rule of 5 violations between desirable and undesirable compounds although one molecule SARA-133 skewed the data with a molecular weight over 3000 (Table 1).
Since considerable acidification can introduce into single-molecule studies undesirable heterogeneities in the protein side chain protonation state, enzymatic activity, reporter photophysics, etc., this problem requires a quantitative analysis.
Half of the drug compounds incorporating the "undesirable" moieties were synthetic organic molecules.
It is well known that MO molecules could elicit undesirable off-target effects such as activation of the p53 protein.
