doi: 10.1038/sj.bjc.6600563 www.bjcancer.com © 2002 Cancer Research UK Suppression of undesirable gene expression is one important object of gene therapy.
Current protocols are usually time-consuming and may imply loss of short-lived RNAs, which is undesirable for expression profiling.
Finally, perhaps another undesirable aspect of the threshold procedure is that it does not deal well with sequences which show increased and decreased expression in equal number of animals.
On the other hand, φ80- attB integration can be used for simultaneous inactivation of an "undesirable" gene whose expression decreases the performance of a producer strain.
However, microarrays require a priori knowledge of sequences that are to be studied, and this renders them undesirable for quantitative expression studies or identification of non-human-specific traits.
They write:[A] parliament with too few representatives is not "democratic" enough, possibly leading to an unstable political system, in which various undesirable forms of political expression, including of course violent ones, will develop.
Expression of undesirable genes can be blocked by the application of antisense gene technology and RNAi technology.
Therefore, endogamy tends to increase expression of undesirable recessive alleles [ 14].
The legal sanctioning of doctors to assist patients in killing themselves may create a new, undesirable conduit for the expression of hostile countertransference.
