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Using RosettaMatch to identify appropriate backbone geometries and a negative design approach to disfavor undesirable coordination environments, the group engineered an octahedral metal-binding site comprised of Bpy-Ala, Asp, Glu, and two water molecules.
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Several theories have focused on the reasons why institutions often fail to pursue reforms for greater efficiency, eventually leading to a path dependent process; some claim that the challenge of institutional coordination effects generates this undesirable outcome [ 8, 22- 24].
Coordination protocols can ensure this consistency, but in practice they cause undesirable performance unless used judiciously.
These two products illustrate examples of potentially undesirable side-reactivities of building blocks that must be considered when rationally designing the synthesis of new coordination polymers.
Pregnant arrestees or those with genuine limitations to their range of rotator cuff motion could be handcuffed in front, which is usually undesirable as an officer, as cuffing in front still allows for pocket access and easy hand-eye coordination.
The highway geometric design guidelines for several countries provide suggestions for the coordination of horizontal curves overlapping with sag vertical curves (sag combinations) to avoid combined configurations that produce undesirable optical effects and reduced safety.
Or undesirable.
"And that is undesirable".
This is highly undesirable.
Both are undesirable options.
But this is not undesirable.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com