For patients who underwent a dose escalation at cycle 2, full pharmacokinetic sampling was repeated in the first cycle at the increased dose.
Not only is arrogance counterproductive in such circumstances, and not only are modesty, fairness, generosity, and compassion better indicated, but most importantly, all such displays of apparent selflessness necessarily undergo a competitive escalation, in close step with that of altruism.
Concepts of risk, reliability, and integrity have undergone an impressive escalation of importance in the decision-making processes of major projects.
Berenbaum (1983) suggested that the plants have undergone an escalation of defenses to herbivory, evolving more and more toxic coumarins.
She underwent a mastectomy.
OSI-930, a dual c-Kit and KDR tyrosine kinase inhibitor, is reported to have undergone a Phase I dose escalation study in patients with advanced solid tumors.
Because of poor tolerability, 12 additional patients underwent a dose escalation regimen (adult, 100 mg daily initial dose up to 200 mg daily maximum; children, initial dose 65 mg/m(2) daily up to 130 mg/m(2) daily).
Internal operations underwent an overhaul this year, with the installation of a consistent Macintosh platform throughout the department.
Our results indicated that quetiapine XR was generally well tolerated by participants, even in the first week when they underwent rapid dosage escalation to a therapeutic dose.
Following diagnosis, clusters of patients needing similar treatment undergo a week of outpatient care delivered by a consistent multidisciplinary clinical team.
Introduction: In the last 30 years, China has undergone a dramatic increase in vehicle ownership and a resulting escalation in the number of road crashes.
