Major efforts were undertaken to rule out methodological artefacts that would render a high false positive rate for mtDNA instabilities and thus lead to erroneous interpretation of sequence instabilities.
Investigations were subsequently undertaken to rule out secondary causes of the optic disc oedema (i.e. toxic, infiltrative).
Additionally, a psychiatric evaluation should be undertaken to rule out any factious disease [ 17, 18, 44, 45].
Every effort was undertaken to rule out concomitant neurologic disease (such as cerebrovascular events, subdural hematoma, Wernicke's disease, drug intoxication) as indicated clinically.
This study does not require the use of unusual, additional tests: only a chest X-ray will be undertaken to rule out a pneumonic process, being a test that is total justified in this project.
This study does not require the use of unusual, additional tests: only a chest X-ray will be undertaken to rule out a pneumonic process and determination of the C-reactive protein during the visit to know the severity of the infection, being a test that is total justified in this project.
Additionally studies have undertaken sensitivity analyses to rule out potential bias from unmeasured confounding which revealed that only very strong unmeasured confounders would explain the observed increased mortality association with conventional antipsychotic use, if in fact, the observed difference was not true [ 22, 28].
In our study we did not undertake a systematic screening procedure to rule out silent events.
To rule out this possibility, confirmatory calculations were undertaken.
Women reporting vaginal discharge were referred to undertake a pelvic as well as laboratory check up- to rule out the presence of RTIs (following informed consent).
