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In our present study, we undertook a screening for antagonists of Wnt signaling from 600 natural compounds, and identified Ginkgetin, a biflavone isolated from Cephalotaxus fortunei var.
We undertook a screening study in a community with a high rate of amputation to determine the burden of neuropathy and to initiate secondary prevention strategies.
In order to contribute to the identification of novel target genes having a potential role in this process, we undertook a screening study by gene expression analysis.
To identify molecules that target M. tuberculosis class II persisters, we undertook a screening campaign using nonreplicating conditions designed to mimic four physiological stresses encountered by M. tuberculosis in one or more of its microenvironments in the host: acidity, reactive nitrogen intermediates, hypoxia, and a fatty acid as a carbon source (6, 16, 18 – 26).
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In the first coupling of genomics and enzymology, Phizicky and colleagues undertook a screen for specific enzymes using large pools of partially purified proteins and specific enzymatic assays.
In order to identify proteins of the Dystrophin-glycoprotein complex conserved at the Drosophila NMJ, and to study these molecules in a model organism, we undertook a screen of many antibodies directed against mammalian DGC proteins, for a specific staining at the third instar larval NMJ.
Since, prior to this study, only five Su TPE) loci were known and we had only been able to identify two additional Su TPE) from our analysis of Su var)s and two from our analysis of the Su z 25 deletion, we undertook a screen designed to identify mutations that suppressed TPE.
To verify these results using an independent approach, we undertook a screen based on mRNA expression profiles, protein localization, and small hairpin RNA (shRNA) depletion.
In this study, we undertook a screen of the uncharacterized index patients for mutations in TINF2 in the largest collection of patients with DC internationally.
To further increase the versatility of the cumate switch, we undertook a screen of CymR mutants to isolate a variant that would bind DNA in the presence rather than the absence of cumate.
Before undertaking a screening trial for cancer, some important factors should be considered.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com