The decision to undertake this trial and its early termination reflect the difficulties encountered when strongly promoted international guidelines might be considered at odds with current best clinical practice, albeit largely derived from experience in quite different geographical and cultural settings.
It is proposed that undertaking this randomised trial is timely and mandatory because: Caesarean section following onset of labour is a major contributor to the alarmingly high overall caesarean section rate.
Prior to undertaking this randomized controlled trial (RCT), we derived a severity-of-illness tool in bronchiolitis patients defining "admission not needed,""length of hospital stay up to and including the median," and "length of hospital stay greater than the median," as ordinal outcome measures.
No validation of self-reported smoking status will be undertaken in this trial.
No quality-of-life assessment was undertaken in this trial 2 and limited resource-use evidence was reported.
Understanding of known genetic mutations and their effects on therapeutic choices such as undertaken in this trial will help us gain the knowledge to improve predictions.
Further, previous research and pilot work undertaken for this trial have noted physician frustration and patient dissatisfaction when assertive patients encounter physicians who are not adequately prepared [ 12, 22].
We undertook this phase I trial to assess the safety, the recommended dose for phase II trials (RPTD), pharmacokinetics (PK), pharmacodynamics (PD), and the preliminary antitumour activity of the combination of lapatinib and sorafenib in patients with advanced refractory solid tumours.
We undertook this randomised controlled trial at St . Raphaelof St. Francis Nsambya Hospital, a periurban private not-for-profit hospital in Kampala, Uganda.
28 We therefore undertook this randomised clinical trial to compare the effects of delayed and early cord clamping on iron status, including haemoglobin, at 4 months of age in healthy, term Swedish infants.
