In order to identify proteins of the Dystrophin-glycoprotein complex conserved at the Drosophila NMJ, and to study these molecules in a model organism, we undertook a screen of many antibodies directed against mammalian DGC proteins, for a specific staining at the third instar larval NMJ.
In this study, we undertook a screen of the uncharacterized index patients for mutations in TINF2 in the largest collection of patients with DC internationally.
We have further developed this assay into a high-throughput format and undertaken a screen of a library of small molecules to look for compounds that can inhibit (or activate) rhomboid activity.
To further increase the versatility of the cumate switch, we undertook a screen of CymR mutants to isolate a variant that would bind DNA in the presence rather than the absence of cumate.
For some attendees the perceived stigma of undertaking a screen test had a negative impact on their willingness to be screened: "I think there's a sort of stigma attached to going for screening"; "If you are not careful you are going to be labelled"; "…because of the stigma"; "Rightly or wrongly it has a stigma".
In our present study, we undertook a screening for antagonists of Wnt signaling from 600 natural compounds, and identified Ginkgetin, a biflavone isolated from Cephalotaxus fortunei var.
To cope with this problem, Morocco is progressively undertaking a screening program based on visual inspection of the cervix with acetic acid (VIA), used as a screening tool in primary health centers, by trained doctors, midwives, and nurses.
The success of nifurtimox as part of NECT prompted the Drugs for Neglected Disease Initiative (DNDi) to undertake a comprehensive screen of 700 nitroheterocyclic compounds for antiparasitic activity.
We undertook a focused screen of chemical compounds that exhibit protein aggregate-binding properties, such as Thioflavin T (ThT) and curcumin, widely used to stain these aggregates in post-mortem tissues of neurological disease affected individuals.
To study the occurrence of polyQ and polyA repeats throughout phylogenesis, and their co-occurrence as found in some expansion-disease-related proteins (e.g. ATX7 and RUNX2, Fig. 1A), we have undertaken a bioinformatics screening of the human and other five eukaryotic proteomes searching for proteins containing repeats of at least four Qs ('Q4'), four As ('A4'), or both.
