Primary outcomes are defined when undertaking hypothesis testing when the aim is to detect a specified effect.
The basis of the method is to undertake a hypothesis test and if justified, repeatedly fit inverted Type I asymptotic threshold exceedance models at discrete frequencies, for which the models are not locked to a block size (as in classical extreme-value models).
Hence to progress multiple experiments must be undertaken per hypothesis and the subsequent results effectively combined to produce a single reliable conclusion.
As understanding of the functional impact of ANK3 on cognition is currently limited we also undertook a hypothesis generating analyses on the effect of allelic variation in ANK3 on other aspects of cognition.
By definition, if one undertakes 20 hypothesis tests on data where we know that there is no true difference, we will expect to see one significant result at the 5% level by chance alone.
9 Subgroup analysis was undertaken for hypotheses exploring differences in clinical relevance and newsworthiness ratings between original studies and review articles.
These enable us to find missing information, generate alternate hypotheses, undertake tasks, get more eyeballs on a problem, or boots on the ground.
What further experiment might you undertake to test the hypothesis that differences in tissue specificity of RNAi might account for the patterns of suppression seen in figure 4 in the accompanying article?
In DIRECT, we are likely to undertake many thousands of hypothesis tests; therefore, determining true from false positive findings will rely on replication studies (in existing epidemiological cohorts linked to DIRECT) and validation studies (in clinical trials that will be undertaken in the second stage of the DIRECT project).
This study was also undertaken with a hypothesis that d-BCP will be a more powerful bone substitute if osteoinductive substances are delivered into the macro-/micropore structures and the central through-hole of d-BCP.
This supports the hypothesis that bees undertake special efforts to stabilize comb temperature by applying heat as near to the brood as possible.
