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These data will permit not only retrospective evaluations of established large cohorts with known outcome data to corroborate these findings but also to undertake correlation with molecular characteristics, such as microsatellite instability and B-raf mutations, which are associated with worse cancer outcomes.
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Hence, we undertook correlations between TLR2 and TLR4 and endotoxin and FFA.
The availability of both the ΔcgrA transcriptome profile (RNA-seq data) and CgrA binding profile (ChIP-seq) allows us to undertake a correlation study to determine which of these 258 DEGs are directly regulated by CgrA and which are indirectly regulated (Tables 1 and Additional file 1: Table S1).
Next, because Flu Trends was previously found to lead CDC ILI Surveillance observations by one to two weeks [2], we undertook additional correlation analyses to determine whether Google Flu Trends or CDC ILI Surveillance had a stronger correlation with CDC Virus surveillance data for the subsequent one or two weeks.
Sensitivity analyses were also undertaken using correlation coefficients of 0.25, 0.5 and 0.75 to determine whether the overall results were robust to the use of different derived correlation coefficients in paired analyses of cross-over trials.
We undertook partial correlation with controlling for Cd excretion because urinary excretion of the renal function biomarkers protein and NAG showed also significant correlations with urinary Cd (Table 2).
In order to investigate whether the expression of the validated targets could be under the control of miR-29a in leukemic cells derived from T-ALL patients, we evaluated the expression levels of miR-29a and of DNMT3a, DNMT3b, and TET1 by real-time PCR, and undertook a correlation analysis.
Correlations were undertaken using Spearman's correlation.
Interpretation of correlations was undertaken using Cohen's correlation effect size descriptors [ 25].
12 18 months after the initial study follow-up, clinical data was sought from a subset of cases in which xSPECT/CT changed the primary diagnosis and imaging correlation undertaken in all patients who subsequently had MRI or CT scans of the same region.
The test-retest reliability of scales was undertaken with Spearman correlation on un-transformed data (to reflect how it is most likely to be used in a clinic setting).
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