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We undertook a phase 1 trial of PF-04929113 SNX-54222), a novel oral HSP90 inhibitor, to estimate the maximum tolerated dose and describe the pharmacokinetic and toxicity profiles.
We undertook a phase II trial to assess the efficacy and safety of single-agent pemetrexed (P) in relapsed small-cell lung cancer (SCLC) patients.
A sudden transition in the time series is a characteristic of a system that undertakes a phase transition, or achieves a new behaviour mode.
> Indiana University undertook a phase I, dose-escalation study of 47 medically inoperable patients with stage 1 NSCLC.
The EORTC Lung Cancer Cooperative Group undertook a phase II study of paclitaxel in 25 chemotherapy-naive patients with malignant pleural mesothelioma.
We therefore undertook a phase I dose-escalation trial of the combination of imatinib, dacarbazine, and capecitabine in advanced endocrine tumors, including predominantly patients with MTC and ACC.
We therefore undertook a phase II study to evaluate the combination regimen of gemcitabine and flutamide for safety, tolerability and efficacy.
The European Commission is undertaking a phased process to amend Directive 2004/37/EC (the Carcinogens and Mutagens Directive), expanding its scope and including and/or revising occupational exposure limit values for a number of cancer- or mutation-causing chemical agents.
The clinical trial center is equipped and staffed to undertake clinical trial phases 1b through 2b in compliance with national and international standards and requirements.
On the basis of this preclinical data, we are now proposing to undertake this phase II randomised clinical trial.
The networks that now exist for the management of these patients provide large patient numbers and high-quality centres that can undertake early phase trials.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com