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A variety of recombinant DNA techniques are available for generating random genetic changes, thus introducing the possibility of uncovering regulatory, kinetic, or unknown/poorly understood targets not encompassed in current models (see [9] for a review).
The LPA GPCR are the most studied and best understood targets of LPA.
One of the best understood targets of MLL are the clustered homeobox (Hox) genes, which play important roles in axial morphogenesis, patterning, and haematopoetic differentiation (Krumlauf, 1994).
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The fetal neural stem cells (NSCs) that generate these neurons are an important but poorly understood target for teratogenesis.
Although the cues governing vascular remodeling are not fully understood, target-derived signals are generally believed to underlie this process.
Finally, as the importance of the stem cell niche becomes better understood, targeting this element of the CSC's biology may prove possible.
One of the easiest ways to understand targets and the effect they have is to think of the health service as a balloon: squeeze one part and it bulges out elsewhere.
More importantly, transgenic Drosophila can be used to better understand targets for protective treatments to preserve cognitive and functional abilities in AD patients.
In order to understand target customers, certain questions must be answered: Who constitutes the market segment?
For decades, marketers have used consumer insights to inform creative and communications strategies, and relied on data signals to understand, target and measure audience reach.
Whether savers understand target-date funds is an important question since their use is growing with the encouragement of the U.S. Department of Labor, which has approved them as a "qualified default investment alternative" for retirement plans.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com