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Although the role of cancer-stem cells is controversial and not fully understood (reviewed by Brennan and Matsui [58]), deregulation of the Hippo pathway has the potential to induce stem cell like properties such as increased proliferative capacity [59].
Due to their significant impact on modern ecosystems and government budgets, a substantial number of studies have examined the effects of invasive species in modern ecosystems, and aspects of their immediate and short-term ecological impacts are well understood (reviewed in Lockwood et al. 2007).
It is comprised of five snRNAs (U1, U2, U4, U5, and U6) bound both to intimately associated proteins that form ribonucleoprotein particles (snRNPs) and a host of other conserved protein factors, many whose function are not well understood (reviewed in [1]).
The pathways of mitochondrial recombination in yeast are not well understood (reviewed in Chen 2013).
The molecular mechanisms underlying cartilage destruction in OA are poorly understood (reviewed in [ 2]).
The mechanisms used to control crossover distribution are poorly understood (reviewed in Phadnis et al. 2011; Youds and Boulton 2011).
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The physical processes responsible for the acquisition of remanence in sediments are poorly understood (see reviews by Roberts et al. 2013 and Tauxe 1993 and within Heslop et al. 2014).
These processes of sporulation and germination are well understood and reviewed in relevant literature (Errington 1993; Driks 2002; Setlow 2003; Piggot and Hilbert 2004; Paredes-Sabja et al. 2011; Higgins and Dworkin 2012).
The role of estrogens in host defense against infections is not fully understood, as reviewed by Marriott et al. [ 33].
"I understood from reviewing materials produced in the litigation that there was another side to the Zyprexa story," Dr. Egilman wrote in the declaration.
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CEO of Professional Science Editing for Scientists @ prosciediting.com