Furthermore, we showed previously that periodic contractions similar to P2 were present in migrating fibroblasts and endothelial cells, and is one of the most fully understood motility modules in migrating cells [10].
There are three data types that Gitools understands: matrices, modules and tables (see Figure 1).
Therefore, a general approach to detect and understand functional modules in a given organism is to simultaneously explore the location of the genes in a given bicluster in the co-expression networks.
In Figure 2 we decided to maintain the relative direction of the syntenic genes as given by Ensembl database (5-3 or 3-5), in order to help the reader understand the modules' position, and provide information concerning the conservation of the orientation of the genes in the investigated species.
Here we aimed a redefinition of functional modules, understood as groups of genes carrying out, cooperatively, a function in the cell.
At a deeper level of analysis, mechanistically defined signatures such as the estrogen receptor (ER -positive signaturER -positiveund-healing signature candbe understhed as regulatory modules, often containing biologically informative substructure, whose expression is controlled by the ER, c-Myc, p53, and other key regulatory proteins [ 10- 13].
Therefore, it is important to understand each module of a vSLAM algorithm to know its performance, advantages, and limitations.
The main motivation in this work is the redefinition of the essence of a functional module, understood as a group of genes carrying out, cooperatively, a function in the cell.
In general, modules are understood as groups of densely interconnected nodes that are only sparsely connected with the rest of the network.
A module is understood as a conceptual grouping of one or several components that provide variants and substitutes to the same functionality [e.g. [ 33]].
