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It is well known that mechanical stimuli play important positive roles in osteogenesis through a still poorly understood mechanism called mechanotransduction. Donahue et al. demonstrated that annexin V (AnxV) was a mechanoreceptor that increased intracellular calcium and thus was associated with bone formation [ 29].
In a poorly understood mechanism, rogue prions "infect" normal prions by changing their molecular shape from a helix to a flat sheet.
The currently understood mechanism of bisphosphonate-induced hypocalcaemia is by osteoclast inhibition.
Past data suggest that the implant itself may have a poorly understood mechanism for extended therapeutic effect.
A poorly understood mechanism is the involvement of the cancer cell plasma membrane composition and architecture and their involvement in regulating drug‐inducing stimuli leading to cell death.
We applied this approach to the exocyst, a hetero-octameric complex of unknown structure that is thought to tether secretory vesicles during exocytosis with a poorly understood mechanism.
One main reason is due to the poorly understood mechanism of Aβ peptide aggregation, which plays a crucial role in the development of Alzheimer's disease.
Amongst the various acid tolerance responses in LAB, the expulsion of protons from the cell through F0F1-ATPase complexes found on the bacterial membrane is the most well understood mechanism.
The transport of cargo across the nuclear membrane is highly selective and accomplished by a poorly understood mechanism involving hundreds of nucleoporins lining the inside of the nuclear pore complex (NPC).
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As the pathogenesis of CNV formation is better understood, mechanism-based therapies, including the use of antiangiogenesis inhibitors, have been investigated.
This comment makes it sound like our paper investigated a well-understood mechanism.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com